Heart Rate Extraction from Novel Neck Photoplethysmography Signals.

This paper demonstrates for the first time how heart rate (HR) can be extracted from novel neck photoplethysmography (PPG). A novel algorithm is presented, which when tested in neck PPG signals recorded from 9 subjects at different respiratory rates, obtained good precision with respect to gold standard ECG signals. Mean absolute error (MAE), standard deviation error (SDAE) and root-mean-square error (RMSE) resulted in 1.22, 1.54 and 1.98 beats per minute (BPM), respectively. HRneck estimation showed strong correlation (R=0.94) with reference HRECG. Good agreement between both techniques was also demonstrated by Bland-Altman analysis. The bias between mean HR paired differences was -0.16 BPM and 95% limits of agreement (LoA) were (-4.7, 4.4). Comparatively, for widely used finger PPG, errors were slightly smaller (MAE=0.38 BPM, SDAE=0.48 BPM, RMSE=0.62BPM) and the correlation with reference ECG was also very close to 1 (R=0.99). Bias of -0.04 BPM and 95% LoA (-1.5, 1.4), also showed high degree of agreement. However, these findings show the potential the neck could have as an alternative body location for wearable monitors, aiming to reduce the number of sensing sites whilst still providing access to a wide variety of physiological parameters

Jupiter as an exoplanet: UV to NIR transmission spectrum reveals hazes, a Na layer and possibly stratospheric H2O-ice clouds

Currently, the analysis of transmission spectra is the most successful technique to probe the chemical composition of exoplanet atmospheres. But the accuracy of these measurements is constrained by observational limitations and the diversity of possible atmospheric compositions. Here we show the UV-VIS-IR transmission spectrum of Jupiter, as if it were a transiting exoplanet, obtained by observing one of its satellites, Ganymede, while passing through Jupiter's shadow i.e., during a solar eclipse from Ganymede. The spectrum shows strong extinction due to the presence of clouds (aerosols) and haze in the atmosphere, and strong absorption features from CH4. More interestingly, the comparison with radiative transfer models reveals a spectral signature, which we attribute here to a Jupiter stratospheric layer of crystalline H2O ice. The atomic transitions of Na are also present. These results are relevant for the modeling and interpretation of giant transiting exoplanets. They also open a new technique to explore the atmospheric composition of the upper layers of Jupiter's atmosphere.Comment: Accepted for publication in ApJ Letter

Implications of a Sub-Threshold Resonance for Stellar Beryllium Depletion

Abundance measurements of the light elements lithium, beryllium, and boron are playing an increasingly important role in the study of stellar physics. Because these elements are easily destroyed in stars at temperatures 2--4 million K, the abundances in the surface convective zone are diagnostics of the star's internal workings. Standard stellar models cannot explain depletion patterns observed in low mass stars, and so are not accounting for all the relevant physical processes. These processes have important implications for stellar evolution and primordial lithium production in big bang nucleosynthesis. Because beryllium is destroyed at slightly higher temperatures than lithium, observations of both light elements can differentiate between the various proposed depletion mechanisms. Unfortunately, the reaction rate for the main destruction channel, 9Be(p,alpha)6Li, is uncertain. A level in the compound nucleus 10B is only 25.7 keV below the reaction's energetic threshold. The angular momentum and parity of this level are not well known; current estimates indicate that the resonance entrance channel is either s- or d-wave. We show that an s-wave resonance can easily increase the reaction rate by an order of magnitude at temperatures of approximately 4 million K. Observations of sub-solar mass stars can constrain the strength of the resonance, as can experimental measurements at lab energies lower than 30 keV.Comment: 9 pages, 1 ps figure, uses AASTeX macros and epsfig.sty. Reference added, typos corrected. To appear in ApJ, 10 March 199

Quantization of Weyl invariant unimodular gravity with antisymmetric ghost fields

The enforcement of the unimodularity condition in a gravity theory by means of a Lagrange multiplier leads, in general, to inconsistencies upon quantization. This is so, in particular, when the classic linear splitting of the metric between the background and quantum fields is used. To avoid the need of introducing such a Lagrange multiplier while using the classic linear splitting, we carry out the quantization of unimodular gravity with extra Weyl symmetry by using Becchi-Rouet-Stora-Tyutin (BRST) techniques. Here, two gauge symmetries are to be gauge-fixed: transverse diffeomorphisms and Weyl transformations. We perform the gauge-fixing of the transverse diffeomorphism invariance by using BRST transformations that involve antisymmetric ghost fields. We show that these BRST transformations are compatible with the BRST transformations needed to gauge-fix the Weyl symmetry, so that they can be combined in a set of transformations generated by a single BRST operator. Newton's law of gravitation is derived within the BRST formalism we put forward as well as the Slavnov-Taylor equation.Comment: 24 pages, 1 table, 1 figur

Caracterização do mercado de manga na União Europeia.

O objetivo desta pesquisa foi fazer a caracterização do mercado de manga na União Europeia, que é o principal mercado importador da manga brasileira. O método utilizado para a execução desta pesquisa foi a entrevista de profundidade, que contemplou importadores, atacadistas, supervisores do setor de produtos hortifrutícolas de supermercados e gerentes de lojas de frutas da Espanha, além de agentes comerciais de outros países comunitários. Os resultados do estudo revelaram que a tendência atual do mercado de manga na União Europeia é de ampliação do consumo. No tocante à conduta de mercado das principais variedades de mangas ali comercializadas se constatou que a Tommy Atkins tem em termos de seu ciclo de vida comercial duas fases: a de maturidade com tendência descendente e a de declínio. A Kent tem a fase de maturidade com tendência ascendente. As variedades Haden e Keitt estão na fase de maturidade estável, enquanto as variedades Palmer, Maya e Shelly encontram-se na fase de crescimento. Com referência à segmentação de mercado de manga fresca, o estudo aponta quatro segmentos bem definidos: o composto pelos consumidores, que priorizam a relação qualidade/preços competitivos, o segmento dos consumidores de produtos prêmios, o segmento dos consumidores de produtos orgânicos e o segmento dos consumidores de produtos minimamente processados ou de quarta gama.bitstream/item/56818/1/BPD92.pd

An improved discrete bat algorithm for symmetric and asymmetric traveling salesman problems

Bat algorithm is a population metaheuristic proposed in 2010 which is based on the echolocation or bio-sonar characteristics of microbats. Since its first implementation, the bat algorithm has been used in a wide range of fields. In this paper, we present a discrete version of the bat algorithm to solve the well-known symmetric and asymmetric traveling salesman problems. In addition, we propose an improvement in the basic structure of the classic bat algorithm. To prove that our proposal is a promising approximation method, we have compared its performance in 37 instances with the results obtained by five different techniques: evolutionary simulated annealing, genetic algorithm, an island based distributed genetic algorithm, a discrete firefly algorithm and an imperialist competitive algorithm. In order to obtain fair and rigorous comparisons, we have conducted three different statistical tests along the paper: the Student's $t$-test, the Holm's test, and the Friedman test. We have also compared the convergence behaviour shown by our proposal with the ones shown by the evolutionary simulated annealing, and the discrete firefly algorithm. The experimentation carried out in this study has shown that the presented improved bat algorithm outperforms significantly all the other alternatives in most of the cases

The circumstellar environment of HD50138 revealed by VLTI/AMBER at high angular resolution

HD50138 is a Herbig B[e] star with a circumstellar disc detected at IR and mm wavelength. Its brightness makes it a good candidate for NIR interferometry observations. We aim to resolve, spatially and spectrally, the continuum and hydrogen emission lines in the 2.12-2.47 micron region, to shed light on the immediate circumstellar environment of the star. VLTI/AMBER K-band observations provide spectra, visibilities, differential phases, and closure phases along three long baselines for the continuum, and HI emission in Br$\gamma$ and five high-n Pfund lines. By computing the pure-line visibilities, we derive the angular size of the different line-emitting regions. A simple LTE model was created to constrain the physical conditions of HI emitting region. The continuum region cannot be reproduced by a geometrical 2D elongated Gaussian fitting model. We estimate the size of the region to be 1 au. We find the Br$\gamma$ and Pfund lines come from a more compact region of size 0.4 au. The Br$\gamma$ line exhibits an S-shaped differential phase, indicative of rotation. The continuum and Br$\gamma$ line closure phase show offsets of $\sim$-25$\pm$5 $^o$ and 20$\pm$10$^o$, respectively. This is evidence of an asymmetry in their origin, but with opposing directions. We find that we cannot converge on constraints for the HI physical parameters without a more detailed model. Our analysis reveals that HD50138 hosts a complex circumstellar environment. Its continuum emission cannot be reproduced by a simple disc brightness distribution. Similarly, several components must be evoked to reproduce the interferometric observables within the Br$\gamma$, line. Combining the spectroscopic and interferometric data of the Br$\gamma$ and Pfund lines favours an origin in a wind region with a large opening angle. Finally, our results point to an evolved source.Comment: accepted for publication in A&

Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer

Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution

Using phage Lytic Enzymes to Control Pathogenic Bacteria

Our laboratory has developed phage lytic enzymes to prevent infection by specifically destroying disease bacteria on mucous membranes and in blood. Enzymes specific for S. pneumoniae and S. pyogenes have been developed to be used nasally and orally to control these organisms in environments such as hospitals and nursing homes to prevent or markedly reduce serious infections by these pathogens. In addition, a B. anthracis-specific enzyme was developed to kill the vegetative forms of these bacteria in the blood of infected individuals. In animal studies, >80% of mice colonized mucosally or infected intravenously with pathogenic bacteria were decolonized or survived after a single enzyme treatment delivered to the same site of colonization or infection